I get similar questions on my mind at times.
In the philosophy of vedic sanatana dharma four human goals are commonly described for every one. 1. Artha (The bare necessities like food, clothing, shelter etc.), 2. Kaama (defined as luxuries - that is anything beyond the bare necessities to live), 3. Dharma (To live according to one's essential nature, to exhaust the accumulated karmas and not add additional karmas) and finally the Moksha (Liberation). It is said that Moksha or liberation is the ultimate goal for everyone. But the others are also accepted as the human goals, because the seekers are at various levels. In order to reach liberation one has to go through the other human goals also. So, the vedic scriptures say that the pursuance of the necessities and luxuries (which would include one's career) of the life are ok, as long as they are done in a proper way (following the dharma).
So, when I set my ishta or desire or bhakti as the Spiritual progress, this is my first and only goal; to progress towards liberation. How do I progress spiritually and attain liberation? I have a family and the responsibilities of a house holder. I have a duty to support my family. Career is an important tool that helps support my family. Therefore performing my career according to the dharma also becomes a goal or ishta. But, I see it more like a sub-category or a tool that helps me to progress towards my primary ishta, rather than two ishtas or desires or goals. The ultimate goal, desire or ishta is the spiritual progress and liberation. But, in order to get there from where I am, I have to exhaust the karmas that I have accumulated. This process of exhausting the accumulated karmas requires me to go through a path that involves pursing the other goals like Artha (bare necessities), Kama (Adequate living for me and family through career, etc.) in the dharmic way and doing service to others and the society without any expectation of results.
So, if I set my Ishta as the liberation or spiritual progress. I see the pursuance of the bare necessities, the career, and some luxuries in a dharmic way as tools that will ultimately take me to my primary Ishta which is liberation. My bhakti is still towards my one and only primary ishta. But that same bhakti towards the ishta guides and drives me to do these other things to go from point A (where I am) to point B which is the liberation.
In conclusion, I feel that directing our energies like a powerful laser beam towards one primary ishta/desire/devotion/goal is more powerful than dissipating the energy in many directions. If the other desires are compliant to the primary goal, and we are clear in our mind that these other ishtas or desries are only tools to help us progress towards the primary Ishta, then it is ok. But there should only be one primary ishta in my opinion.
Regards,
Ram.